Abstract: The regional concept - "Indo-Pacific region" has become a popular topic for research in modern international politics with the active promotion of four countries (USA, Japan, India and Australia). The Indo-Pacific strategy championed by the US Trump administration is the most significant among them and has strengthened the use of the emerging regional term "Indo-Pacific region". After the trade war, relations between China and the United States deteriorated, and Sino-American relations have become one of the most important relations in the field of international relations in this century, and the Indo-Pacific Strategy of the United States, developed under Trump, remains one of the concrete manifestations of the Sino-American great power game. This article explains the evolution of the concept of the "Indo-Pacific region", and the formation and development of the Indo-Pacific Strategy of the United States, as well as explains the fundamental goals of the Indo-Pacific Strategy of the United States and the structural conflict in the geopolitics of the Indo-Pacific region through generalizing the views and opinions of Chinese academia about the U.S. strategy in the Indo-Pacific region. The strategy and policy of the United States in the Indo-Pacific region pursues the main goal of maintaining US hegemony, and this is also closely related to the rise of the PRC. Massive military commitments and a large number of US armed forces in the Indo-Pacific region and the growth of the military power of the PRC will become the most central contradiction in the geopolitical structural conflict between the PRC and the USA in this region. The US military policy in this region will cause discontent of the PRC and even regional conflicts, but at the same time it should be noted that due to the firm strategic determination of the PRC, the PRC's own economic development and the limitations of internal factors of the USA, the US Indo-Pacific strategy will not hinder the peaceful growth of the PRC in this region.