Abstract: The research object is the criminogenic aspects of the economic situation in the Russian Federation. The research subject includes the patterns and tendencies of emergence and development of economic crime in the Russian Federation; criminal legal prohibitions of wrongful deeds in the economic field; law enforcement practice of struggle against economic crimes committed by organized groups and criminal organizations. The purpose of the research is the development of scientifically-grounded suggestions and recommendations aimed at raising the effectiveness of enforcement of economic crimes committed by organized groups and criminal organizations. The research methods include content-analysis of documents, analysis, synthesis, description and comparison. The scientific novelty of the research consists in the theoretical analysis of the essence of struggle against economic crimes committed by organized groups and criminal organizations. Some other provisions of the article are remarkable for their scientific novelty, particularly: a) the authors outline the features of modern organized criminal groups and criminal organizations; b) the authors define the main directions of criminal aspirations of organized criminal groups in the economic field; c) the authors outline the methods of economic crimes committing used by organized groups and criminal organizations. The key findings of the article are: based on the established tendencies and patterns, the authors believe that the main directions of the further improvement of internal affairs bodies’ activities, particularly the investigation activities of economic security and anti-corruption enforcement units, in the field under consideration, will be the improvement of the work of specialized internal affairs units and their involvement in solving the tasks of struggle against economic crimes committed by organized groups and criminal organizations by means of subversive operations against economic and financial grounds of criminal organizations and their corrupt connections, and by means of effective information and analytical work, prognostication, planning, internal and external interaction.