Abstract: The concept of open innovation, which emerged in the early 2000s, has now been put into practice. Using the example of many firms, it was found out that the skillful use of the methodology of open innovation makes it possible to make a qualitative leap in the development of advanced technologies, while in a short time and with significant resource savings. However, not all firms and not always manage to achieve decisive success in using open innovations for growth and competitiveness. This study shows that the reason for this is the wrong choice of a strategy based on open innovation, as well as the inconsistency of even a correctly chosen strategy of the company's business model. To overcome it, organizational changes are required that will ensure the compatibility of the strategy and a business model acceptable for its implementation. The concept of the relationship between open innovation strategies and their corresponding business models developed in the article makes it possible to make the work of designers of a company's growth and development strategy based on open innovations more rational and productive, and to reduce the likelihood of strategy failure during its implementation. A systematic study of the impact of various open innovation strategies on the development of business models should be continued in terms of specifying such an impact depending on the scope of the company's activities, its size, structure, specifics of business processes, cultural traditions, methods of stimulating staff receptivity to open innovation, leadership styles, communication systems and organizational power structure.The main objective of the open innovation strategy is not to implement deep integration of external sources into the activities of an innovative company, but to provide opportunities for the development and implementation of a business model that ensures close cooperation of the company with its external partners and mutual exchange of knowledge between them.