Abstract: The relevance of this research is substantiated by the fact that currently there exists a number of the state conceptual documents on the development of economic security of Russia; however, the unified organizational-economic mechanism of strategic management of the country’s economic security is yet to be developed. Within the framework of this article, the authors selected the meso-level analysis. The object of study became the Perm Krai and Vladimir Oblast (the small cities were chosen for demonstrating the regional level of the system of economic security of Russia). An important selection criterion was the remoteness from the capital region. Verification of dependence of the separate structural indexes of components on the mechanism of economic security of Russia will allow more efficiently managing the regional development – the basic of economic security of Russia particularly forms at the regional level. The absence of the scale of existing indexes and their assessment prior to this research confines the development of regional potential, because the strategic management requires the rational allocation of the provided resources meeting the actual needs in order to ensure the necessary balance – the suggested scale of the level of structural indexes is aimed at solving this issue. The authors observe the intercorrelation between not only the components of organizational-economic mechanism of strategic management of economic security, but also each of the structural indexes that form the importance of components in the mechanism. The subsequent vector of research can become the determination of the entire list of significant indexes of all components of the organizational-economic mechanism of strategic management of economic security of Russia, as well as the emergence of the analytical model of the system of economic security, which will be an effective instrument for formation of the development strategy of Russia.