Abstract: The process of formation of the existing system of counteraction to legalization of proceeds from crime, which is based on the principles of interaction between financial, administrative institutions and law enforcement bodies, is considered in the work. Unlike the United States and Great Britain, the Ministry of Economy and Finance is responsible for developing policies to counteract money laundering in Italy.The authors of the paper analyze the activities of the national financial intelligence unit of Italy - L'Unità di informazione finanziaria per l'Italia (UIF), established in accordance with Legislative Decree 231/2007 as an independent body within the structure of the Bank of Italy, as well as the National Commission for Companies and The stock exchange and the Institute for Insurance Supervision. Based on the data received, the authors draw attention to the fact that Italy has a well thought-out regime for countering the legalization of proceeds from crime through a well-developed legal framework. During the research, the authors have used historical, logical, statistical, systemic and prognostic methods of investigation. The main conclusion of the research is that the distinctive feature of the Italian system is the close interaction of the national financial intelligence unit with the Bank of Italy, formally independent but essentially structural subdivision thereof. Involvement of other state authorities also contribute to increasing efficiency of combating money laundering.