Abstract: The economic landscape of Russia is territorially variable, which is due to the difference in the potentials, as well as to differing value of regions in global economic connections. At the same time, some regions have economically favorable bordering position, which may be considered a benefit in the international cooperation, and a prerequisite of successful integration of such territories into global economy. Having studied the development of the Republic of Karelia, the authors come to a conclusion, that unlike many bordering regions, the Republic of Karelia does not fully use the positive effects of its geographic position in order to attract foreign investors. However, it is an important dimension of foreign economic relations, since it allows for greater innovative potential and competition advantages, and it strengthens the effects of participation in the international differentiation of labor. Participation of foreign investors is not obvious, therefore, Karelia is among the regions with low level of foreign investments. The authors come to a conclusion that the borderline factor is evened out by the peripheral position, and a number of other factors, including the small number of population. When placing their enterprises, the foreign investors are attracted by the regions with developed economic and transportation infrastructure and high customer potential. The theoretical bases of the Standort theories, the theories of production placement, and central position theories, allowing for best territorial position from the standpoint of less production costs and maximal profits of the owners, are being proven, and the retail zones of enterprises still have a defining role.