Abstract: The research subject is the patterns of formation and use of the results of investigation activities based on information support of economic security and corruption combating unites in the struggle against corruption in the field of road traffic safety. The author considers and studies some peculiarities of organizing information support and analytical work in the context of effective corruption combating in the field of road traffic safety. Special attention is given to the mechanism and the sources of information forming, the most effective levels of information and analytical work, and the role of analysis in comprehensive use of information for combating corruption in the above mentioned sphere. The research methodology is based on the fundamental provisions of epistemology, the system-structural and system-pragmatist methods. The author develops the practically efficient method of information support of economic security and corruption combating units aimed at detection, investigation and prevention of corruption in the field of road traffic safety. The method is based on information and analytical work, taking into account various conditions and situations occurring at operative support of this sphere, and its significance when implemented within an organization aimed at solving operative, tactical and strategic tasks.