Статья 'Модель эндокринной подсистемы и расчеты параметров инъекций' - журнал 'Кибернетика и программирование' - NotaBene.ru
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Cybernetics and programming
Reference:

Model of endocrine subsystem and calculation of injection parameters

Kormilitsyn Aleksandr Yur'evich

Deputy Director, INKART (St. Petersburg)

199155, Russia, Saint Petersburg, ul. Semenovskaya, d. 4, of. 1

alex_kkk@incart.ru
Skorubskiy Vladimir

PhD in Technical Science

Associate Professor, Department of Computer Engineering, ITMO

199155, Russia, Saint Petersburg, ul. Morskaya Nab, 45, kv 55

vskorubski@yandex.ru

DOI:

10.7256/2306-4196.2015.1.13655

Review date:

12-11-2014


Publish date:

20-01-2015


Abstract: The human body is seen as an information system. An endocrine subsystem is selected for the study. The authors use data on the level of sugar in blood to calculate it’s dependencies for healthy patients as well as for patients with second type diabetes during control intervals between injections. Authors propose a generalization in a form of mathematical model for autoregulation of these processes in endocrine system using natural internal and medical external injection of insulin and glucose. The model should be used for calculating time intervals between possible critical states of patients and parameters of external deflection compensation of concentration (the intake of dietary carbohydrates and insulin injections) to maintain the normal state of patient. Dependencies of the concentration of sugar in the blood that define the state of endocrine subsystem can be presented in form of continuous exponential graphics with typical monotonous increase and decrease. This allows suggesting the dependence of the control law as a polynomial with coefficients which are specified in real time at the control points. The use of interpolation and extrapolation help to predict the nearest glucose concentration level in the blood based on the accumulated data measured by portable glucometers and, most importantly - to predict extreme states of hyperglycemia and hypoglycemia and perform an approximate calculation of parameters of external insulin and glucose injections. The article present a new model of human endocrine subsystem for diabetes and gives recommendation on use of injections to maintain normal life. The described model is simple and can be efficiently used for controlling the state of patient and calculating the parameters of the external injection (the intake of dietary carbohydrates and insulin injections) for maintaining a normal state using available mobile measurement and evaluation means.


Keywords: endocrine system, glucose concentration, insulin injections, injection of glucose, glycemic Index, hyperglycemia threshold , hypoglycemia threshold , information model, model of regulation, homeostasis
This article written in Russian. You can find full text of article in Russian here .

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