Abstract: The subject of this research is the activity of John Jacob Astor and his role in the American opium smuggling trade. Description is given to the differences between the American and British opium models in China. An attempt is made to determine the peculiarities of Astor's activity in the opium business. The article employs the following sources: works of the German historian Alexander Emmerich from the University of Augsburg dedicated to the American Germans and their fate in the United States; work of the American historian John (Jake) Chen on the history of Chinese diaspora in the United States; work of Jeff Goldberg who specialized in the history of psychotropic substances; article by the member of the Massachusetts School of History Fredrik Delano Grant, Jr. on the Roosevelt’ opium track’ text of the debate in the British Parliament of April 9, 1840. The novelty of this research lies in familiarization of the Russian-speaking audience with the problems of opium smuggling trade through the research works that have not been previously translated into the Russian language. The conducted analysis of the parliamentary debates in Great Britain determines the commonality of interests of the British and American opium traders with regards to China. The study confirmed the enormous fortune of John Jacob Astor in the American opium smuggling trade, although this type of commercial activity was not primary in his business. The article also describes his continued commercial activity (including opium) in the United States after leaving the Chinese market.