Abstract: The article provides the results of a study to identify the specifics of Russian-American relations in the field of international information security (IIS) and the potential for its development in the digital environment in the 21st century. The author considers such aspects of the topic as the approach of Russia and the United States in the field of ensuring IIS; Russian-American relations in the field of IIS. Particular attention is paid to the consideration of the specifics of Russian-American relations on IIS issues, as well as to the extent to which they have an impact on modern international security in the period from 1998 to the present. The main conclusion of the study is that the IIS is an important component of bilateral relations between Russia and the United States, and the nature of relations on this issue has an impact on the international system, but it has a certain autonomy being inscribed in a broader geopolitical context. The author's special contribution to the study of the topic is the use of the case study method to identify the role of cyber sanctions within the IIS in general and Russian-American relations in particular. The novelty of the study lies in conducting a comprehensive analysis of the issues of IIS in the context of modern bilateral relations between Russia and the United States and the trends of the international system, including the study of the impact of new information and communication technologies on modern international security and strategic stability.