Abstract: An evident technological progress in the area of preservation of life and improvement of its quality, also due to dynamic development of transplantology, is accompanied by active antagonism towards this process, caused by diverse phenomena. In a number of cases, such attitudes are a threat to human life and wellbeing, although in some situations may manifest as the factors of healthy conservatism. Among these phenomena are the religious beliefs that take roots in the archaic “stages” of mental reality (which does not mean automatic inadequacy). All these occurrences require meticulous scientific examination. The authors apply multidisciplinary approach that includes in-depth psychological, religious, philosophical and medical approaches. The following conclusions were made: 1) among a significant amount of churched believers attributed to both Christian and Muslim faiths, the topic of transplantology is associated with a strong unconscious conflict; 2) this conflict is also referred to the sphere of archaic religiousness that partially relates to the perception of “shadow” sides of human psyche and to the “paranoid-schizoid” layer; 3) based on the aforementioned arguments, there is a need for conducting an additional large-scale research of defense mechanisms emerging in the context of perception of the phenomena of transplantology; 4) some believers should clarify the attitude on transplantology for themselves (either negative or positive); no obvious differences are determined between the Orthodox or Muslim believers with regards to transplantology.