Abstract: The object of this research is the clusters included into the register of the Ministry of Industry and Trade of Russia (Minpromtorg). Keeping the production in line with the scientific and technological progress for manufacturing high quality import-substituting products is defined by the capabilities and industrial structure of the clusters. For examining the aforementioned aspect, the study reviews and generalizes the basic characteristics of the subjects of production of the 28 industrial clusters included into the register of Minpromtorg of Russia. Focus is made on determination of peculiarities in the industrial structure of clusters depending on their specialty and affiliation to certain districts of the Russian Federation. The following conclusions were made: the industrial structure of clusters included into the register of the Ministry of Industry and Trade of Russia depends on their specialty; in quantitative ratio between the large, medium and small businesses of the industrial structure of cluster formations, usually dominates the number of small business enterprises; the industrial structure of cluster formation clearly demonstrates the role of clusters as the instrument for development of small business. The authors’ special contribution into the research of this topic lies in determination, analysis and generalization of the industrial structure of clusters included on the register of Minpromtorg of Russia. The scientific novelty consists in the quantitative and qualitative analysis of the industrial structure of clusters under consideration. The article is prepared within the framework of the research and development project XI.172. 1.2. (0325-2017-0002) “Scientific Bases of the Regional Cluster Policy of Russia” of 2018; state registration number is АААА-А17-117022250124-7.