Abstract: The subject of this research is the key trends in activity of the Sisters of Mercy in Altai Krai, on the example of Alexander Nevsky Cathedral in Barnaul. This place has accumulated an extensive experience of rendering spiritual, humanitarian and social aid to the ill parishioners, however officially it was recognized since January 2019. The Sisters of Mercy gather on the weekly basis, associate with the priest, read Akathist Hymn to the Holy Martyred Nun Elizabeth, visit the patients. The method of in-depth interview was selected for the analysis of activity of the Sisters of Mercy, as well as receive answers to the questions pertinent to suggested hypotheses. The research results allowed determining that sisterhood in Barnaul is currently relevant and not considered an innovation. It is also highlighted that the Sisters of Mercy from Alexander Nevsky Cathedral in Barnaul render assistance not only to the ill, elderly, orphans and multi-child families, but to all in need; however their care and spiritual support is focused mostly on bedridden patients and elderly people. The conducted analysis demonstrates active development of this direction and attraction of new people eager to help, as well as underlines the need for expanding the sisterhoods in Barnaul churches.