Abstract: On the basis of a new methodology for assessing the current state of innovative development of the region, a decision-making information support system (DSS) has been developed when developing an innovative development strategy for a region. The generalized structure of the decision support system, the description and purpose of its main modules are given. Approbation of the work of the DSS on the example of the Republic of Bashkortostan was carried out. The received recommendations are necessary for the state authorities of the constituent entity of the Russian Federation to form an effective plan of measures, taking into account the current state and the existing opportunities for innovative development of the region. The study is based on general scientific methods of knowledge.(analysis, synthesis, comparison), the presentation of tabular and graphical interpretation of empirical-factual information. The theoretical and practical significance of the study is due to the relevance of the studied problems of assessment, forecasting and planning of innovative development of territories when developing regional development strategies. The practical result of the research is the approbation and implementation of the proposed approaches in the development of an information decision-making support system necessary for obtaining recommendations on the formation of an effective action plan for an innovative development strategy for a region that takes into account the current state and available capabilities of the territory.