Abstract: The present article is devoted to the phenomenon of burn-out in the process of cross-cultural communication. The purpose of the research is to study the phenomenon of burn-out in the process of cross-cultural communication. In his research Larin introduces a new theoretical construct - burn-out caused by cross-cultural communication or 'cross-cultural burn-out'. He has also tested a new inventory to analyse burn-out caused by cross-cultural communication. Based on the results of his research, the author has developed two scales for measuring the level of cross-cultural burn-out and evaluation system to measure the general cross-cultural burn-out factor. In addition, the author has also applied such methods as questionnaire survey, scaling and testing (MBI - Maslach Burnout Inventory - adapted by Vodopyanova and the author's Cross-Cultural Burn-Out Inventory). The article presents the results of testing the Cross-Cultural Burn-Out Inventory and data received by the author based on that test. Based on the results of his research, Larin has defined two cross-cultural burn-out factors that relate to burn-out indicators. To measure the general level of cross-cultural burn-out, the author has developed an integrative index of cross-cultural burn-out that has a high correlation with all burn-out indicators described by Maslach.